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Preclinical and Clinical Evidence of CIPN: Major Antioxidants in Lines of Defense Melatonin Melatonin, which is synthesized by all kinds of cells, is principally secreted by the pineal gland and is known for maintaining aging, reproductive function, circadian rhythm and antioxidant activity [37]
However, more laboratory and clinical trials are required to confirm the potential protective effects of spirulina and TQ
Validated aging biomarkers: Current research relies on indirect markers such as oxidative stress and inflammation

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