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Oxidative Stress At the end of the experiment, oxidative stress in the collected tissue samples (brain, heart, lung, liver, kidney, stomach, small and large intestine, and blood) was assessed by quantifying the thiobarbituric acid-reactive species (TBARS) as malondialdehyde (MDA) [9,10,12,13,14,19,20]

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Though only a single layer of cells, the intestinal epithelial cells (IECs) are the mainstay of the intestinal barrier and serve as a physical barrier (Figure 1)

The molecular docking results revealed that the VPA and CBZ compounds could interact with the identified targets active sites, and thus, the identified proteins may be suited for oxidative stress mediated therapy in epilepsy