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Effects and mechanisms of rifampin on hepatotoxicity of acetaminophen in mice

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1 Introduction Radiation therapy stands as one of the most effective modalities for cancer treatment, applicable to over half of all cancer patients ( While advanced imaging modalities such as abdominopelvic computed tomography (CT), magnetic resonance enterography (MRE), and confocal laser endomicroscopy (CLE) provide critical insights into morphological changes, their reliance on anatomical visualization restricts early functional assessment and prognostication ( Despite these advances, current management strategies remain predominantly palliative, relying on anti-diarrheal agents, corticosteroids, and surgical interventions that fail to address the underlying pathophysiology of RIII ( Recent preclinical and clinical studies have achieved significant progress, demonstrating that natural plants and their derivatives, traditional Chinese medicine (TCM), drug repurposing, mesenchymal stem cells (MSCs), and gut microbiome regulation can all serve as potential treatments for RIII

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