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Acknowledgements We thank the Seoul National University Institutional Animal Facility

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J.AguilarB

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3 Drug repurposing 3.1 Significance of drug repurposing Drug repurposing can shorten development times by 57 years, reduce research investment costs by accounting for less than 10% of new compounds, and avoid risks such as a constant weight of generics (Turanli et al., 2021)

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Peer review Peer review information Nature Protocols thanks Ilaria Armenia, Stefano Fedeli, and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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