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Notably, substitution with hydroxy groups on the pendant phenyl was well tolerated with the 2- and 3-OH derivatives, 68 and 69 , exhibiting comparable potency to the top analog 43 at IC 50 values of 14 M and 15 M, respectively
Glial-neuronal interactions as studied by cerebral metabolism of [2-13C]acetate and [1-13C]glucose: an ex vivo 13C NMR spectroscopic study
and inhibition of nuclear factor, erythroid 2related factor 2, a factor encoding for antioxidant proteins (57)
doi:10.1371/journal.pmed.1000050
