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majority of TBI and stroke studies Mice Used for transgenic Alzheimers models (APP, APP/PS1) and excitotoxicity studies Humans Multiple clinical trials in stroke, dementia, and TBI populations Cell culture Cortical neurons, hippocampal cultures, endothelial cells for mechanistic studies Research Limitations & Regulatory Status Critical Gaps in Current Evidence Despite over 1,000 preclinical studies and numerous clinical trials, Cerebrolysin faces substantial translational challenges that significantly limit its therapeutic utility

doi: 10.1007/s10495-015-1136-y, 50

These explanations are speculative in nature and future research may dig deeper in the origin of the relationship among these neurometabolites

doi: 10.1016/s0891-5849(02)01360-6, 12