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The most realistic expectation is supportive, gradual change rather than immediate effects

B12 holds a rate limiting effect on two key enzymes that work within the energy cycle and the methylation cycle (Remember methylation is how we make new molecules, like myelin, creatine, DNA for news cells and break down or converts others things like hormones, toxins, serotonin to melatonin etc)

The more glutathione in circulation, the better the body is at combating oxidative stress and preventing the associated diseases