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FIGURE 2 2 UPRmt-driven cross-tissue signaling under mitochondrial stress During aging and aging-related diseases, hepatic mitochondrial function progressively declines, accompanied by reduced efficiency of MQC systems, including attenuated or dysregulated UPRmt activation
Oxidative stress induced by P2X7 receptor stimulation in murine macrophages is mediated by c-Src/Pyk2 and ERK1/2

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