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Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis

Among these are pro-inflammatory cytokines, chemokines, and inducible enzymes such as nitric oxide synthase (iNOS) and cycloxygenase-2 (COX-2)

Thus, in situ produced microbial folate may favourably influence the cellular nutrition of the local colonocytes and may be important in maintaining intestinal homeostasis and modulating gut microbiome function, e.g., through regulation of colon mucosal proliferation (i.e., colorectal cancer prevention) and its anti-inflammatory effects 248,249,256,257,277,278,279,280,281,282,283,284,285,286

Pt(IV) compounds that have recently been investigated in this context include complexes with the histone deacetylase inhibitors valproate and phenylbutyrate as the axial ligands as well as with dichloroacetate which is a known apoptosis sensitizer and anticancer agent reverting the Warburg effect 30,31,32