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Its ability to accelerate healing across multiple tissue types makes it uniquely valuable in both clinical and performance settings

(4) increased hepatic and renal urea cycle intermediates suggesting hypercatabolism and upregulation of the urea cycle independent of impaired renal clearance of nitrogenous waste

Of the six known IGFBPs, IGFBP-3 is by far the most common, accounting for around 80% of all bound IGF-1, typically forming a 150 kDa tri-molecular complex with it and the acid-labile subunit (ALS), known as the IGF-1-IGFBP-ALS complex [21]

doi: 10.1007/s12640-018-9866-6
