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Notably, despite caspase-1s essential role in IL-1 maturation, its involvement in GSDMD cleavage was excluded by comparable GSDMD-N elevation in Casp1 KO and WT cochleae after noise exposure (Fig
2018;28:93340.e4
It establishes cellular antioxidant defense by transcriptionally activating antioxidant genes (e.g., SOD2, CAT, GCL) and reductive molecules (e.g., GSH, Trx), while downregulating pro-oxidant molecule synthesis, thereby directly scavenging or neutralizing excess ROS [134]
Among all of the analyzed vaccine candidates in this study, BB0172-derived peptide, recombinant OspA along with meningococcal outer membrane vesicles, recombinant P66, recombinant VISE, and chimeric OspA revealed stronger positive effect ( Figure 4 )
