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Funding The author declares financial support was received for the research, authorship, and/or publication of this article

Co-stimulation with IL-1 and TNF- induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system

Tight regulation of CDO activity may facilitate maintenance of relatively low steady-state Cys concentrations so that Cys is available for essential functions (e.g., protein, CoA, glutathione, and H 2 S synthesis) while also preventing high Cys concentrations, which could be toxic

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