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Intriguingly, recent investigations have demonstrated that irisin upregulates the expression of TFAM (mitochondrial transcription factor A) through the activation of the SIRT1/PGC-1 signaling pathway, thereby enhancing mitochondrial metabolism and mitigating microglial activation 18

Life Sci 32:19491955 Boussicault L, Herard AS, Calingasan N, Petit F, Malgorn C, Merienne N, Jan C, Gaillard MC, Lerchundi R, Barros LF, Escartin C, Delzescaux T, Mariani J, Hantraye P, Beal MF, Brouillet E, Vega C, Bonvento G (2014) Impaired brain energy metabolism in the BACHD mouse model of Huntingtons disease: critical role of astrocyte-neuron interactions
the individual tissues and the cellular compartments have been discussed by Courbet et al
