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Mechanistically, intranasally administered agents may be absorbed through the olfactory epithelium or trigeminal nerve endings and transported to the brain via extracellular diffusion and intracellular axonal pathways, which may partially bypass BBB-related constraints (Raghav et al., 2023
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Die Harnstoff-Biosynthese ist reguliert und kann sich anpassen: Bei hoher Proteinzufuhr kommt es zur Induktion von Enzymen des Harnstoffzyklus, d.h
In our experimental design, we established a D-galactose-induced aging mouse model and injected the experimental group mice with FOXO4-DRI for 1 month, while the control group was injected with equal amounts of PBS
