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Activated mTORC1 drives lipogenesis primarily by upregulating the transcription factor SREBP1 [127], and concurrently suppresses FAO by inhibiting carnitine palmitoyltransferase 1 (CPT1) [128]
Furthermore, one important characteristic of 23 (HA08) is its high 2,000-fold selectivity for IRAP over AP-N and high selectivity vs
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