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Adjunctive supplementation with folic acid and vitamin B6 enhances recovery by supporting the methylation cycles and reducing neurotoxicity (Algahtani et al., 2020)

USA 2002;99:1876-81

Albuminuria, serum antioxidant enzyme levels and markers of hemolysis and inflammation in steady state children with sickle cell anemia

Evaporative cooling (applying cool water plus air movement -- fan, breeze, air conditioning) for any dog is the next best option
