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Know what side effects you consider acceptable and what would prompt you to stop

Liang, Y., et al
Mitochondrial Dysfunction in Type 2 Diabetes and Obesity Well established data demonstrate that mitochondrial dysfunction, particularly as it relates to the processes of oxidative phosphorylation, is contributory to the development of encephalomyopathy, mitochondrial myopathy, and several age-related disorders that include neurodegenerative diseases, the metabolic syndrome, and diabetes

Niacin (nicotinic acid) has been classified as pregnancy category C
