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Nrf2 inhibitor, brusatol in combination with trastuzumab exerts synergistic antitumor activity in HER2-positive cancers by inhibiting Nrf2/HO-1 and HER2-AKT/ERK1/2 pathways

315 YiC.MeiX.EzanP.MatoS.MatiasI.GiaumeC.et al (2016)

Conditions like pancreatitis can occur when gallstones migrate to the common bile duct, obstructing pancreatic ducts

Both areas are separated by a long ATAAA repetitive stretch, which probably acts as an insulator to separate different epigenetic states such as methylation of the CGIs (Millar et al., 2000)
