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Lancet 351(9101):490493 Schaefer AM, Phoenix C, Elson JL, McFarland R, Chinnery PF, Turnbull DM (2006) Mitochondrial disease in adults: a scale to monitor progression and treatment

For health maintenance, low-dose, pulsed radical species (e.g., from exercise) act as essential signaling mediators that potentiate adaptive responses in metabolism and mitochondrial homeostasis, benefits contingent upon strict dose control

Soluble Fas ligand (sFASL): Soluble Fas ligand (sFASL) is the circulating form of membrane-bound Fas ligand, a member of the TNF superfamily, and plays a critical role in regulating apoptosis and immune responses

Second, they harbor enzymes negatively regulating T effector cell functions, such as nitric oxide synthase (NOS) and Indoleamine 2,3-Dioxygenase (IDO) (Munn et al., 2005