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Moreover, PARP inhibition reportedly prevented the recruitment of FET proteins, while PARG inhibition prolonged the presence of FET proteins in DNA damage sites in vitro, which was also observed in hnRNP A1 and TDP-43 131

The ANLS hypothesis proposes a coherent model where glutamate uptake by astrocytes stimulates their glycolysis, leading to lactate production and export, which is then taken up and oxidatively metabolized by neurons to meet activity-dependent energy demands (Brooks, 2018

Subsequently, trifluoromethoxy-carbonylcyanide phenylhydrazone (FCCP) was titrated to achieve maximum flux through the electron transfer system
