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Hydrocodone withdrawal progresses through five sequential phases: Hours 6 to 12: Anxiety, restlessness, yawning, lacrimation, and rhinorrhea emerge as locus coeruleus noradrenergic neurons reactivate without opioid suppression Hours 12 to 24: Myalgia, abdominal cramping, diaphoresis, piloerection, and insomnia intensify as sympathetic nervous system hyperactivity reaches its early peak Days 1 to 3: Nausea, vomiting, diarrhea, tachycardia, and hypertension reach maximum severity