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Indole-3-acetic acid (IAA), produced by gut microbiota, alleviates fibrosis by suppressing PI3K/AKT/mTOR signaling, enhancing autophagy, and reducing fibroblast activation and epithelial senescence [114]

Analytes were separated on a 100 2.1 mm, 1.7 M Acquity UPLC BEH C18 Column (Waters), with a 0.2 ml min 1 flow rate and with a gradient of solvent A (97:3 H 2 O/methanol, 10 mM TBA, 9 mM acetate, pH 8.2) and solvent B (100% methanol)

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