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Patient-derived xenograft models were conducted in accordance with established guidelines, having obtained written consent from the respective patients, and received approval from the Second Xiangya Hospital of Central South University (2020591)

Moreover, carcinoma cells that decouple the TGF- pathway from apoptosis can respond to TGF- with invasion, dissemination, and metastasis, thus leading to tumor progression instead of tumor suppression

Because it has a carboxylic acid moiety on the side chain, glutamic acid is one of only two amino acids (the other being aspartic acid) that have a net negative charge at physiological pH

In contrast, PRX3 expression in control cells was associated with extensive tumor burden (Fig