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Intracellular methionine level of CD19 + B cells is largest increased after CpG/IFN-/BCR crosslinking simulation, and methionine commits the differentiation of CD19 + B cells through driving the histone modification H3K27me3 of BACH2 (a vital transcriptional factor for B-cell differentiation), and this process refers to activation of spleen tyrosine kinase (Syk) or mTORC1 signaling and up-regulation of expression of methyltransferase enhancer zeste homolog 2 (EZH2) (105)

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Metabolomics can clarify curcumins metabolic pathways and its interactions with other drugs or dietary elements (Manickavasagam et al., 2024)

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