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In vitro prophylactic injection of IL-22 can significantly reduce the expression of pro-inflammatory factors IL-6, IL-1, TNF-, and the liver necrosis area and increase the expression of hepatocyte proliferation marker Ki-67, suggesting that IL-22 through promoting hepatocyte proliferation mediates hepatoprotective functions and has the therapeutic potential in AILI [174]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 89.Ripoli C., Dagliyan O., Renna P., Pastore F., Paciello F., Sollazzo R., Rinaudo M., Battistoni M., Martini S., Tramutola A., et al