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Two patients (one epilepsy, one mixed) with IDDM had worsening hyperglycemia with steroids without benefit from treatment

SAM levels were decreased, but S-adenosylhomocysteine (AdoHcy, SAH) levels were elevated considerably, with global DNA hypomethylation observed in both heterozygotes and homozygotes 38

[DOI] [PubMed] [Google Scholar] 8.Yuan L, Kaplowitz N
Benowitz, 2024)