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The agency also explains that severe calorie restriction, rather than hCG itself, accounts for the body-weight change seen in those plans

Pregnancy and Breastfeeding : If you are pregnant, planning to become pregnant, or breastfeeding, consult with a healthcare provider before using any peptides

Particularly in cases in which the apparent loss of auto- or heteroreceptor activity could be caused by downregulation of receptor expression, it is possible that pharmacological activation of the remaining receptor population would be insufficient to restore modulation of neurotransmitter release