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doi: 10.1016/j.neulet.2022.136885
Its dramatic age-related decline is significant: plasma concentrations average 200 ng/mL at age 20 but typically plummet to 80 ng/mL by age 60a 60% reduction correlating with visible aging and reduced healing capacity
doi: 10.3389/fphar.2021.693048 218
In summary, these research findings collectively emphasize the foundational and complex role of DNA methylation mechanisms in regulating neuronal development, maintaining neuronal function, and supporting cognitive abilities
