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Curcumin interfering with proliferation and energy metabolism in colorectal cancer: 3D tumor model and computational simulations reveal curcumin inhibition of HSPD1 and CALCOCO2European Journal of Pharmacology | July 2025Curcumin inhibits proliferation and promotes oxidative stress and programmed cell death in colorectal cancer cells

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Peroxynitrite induced obvious nuclear distribution of NF-B p65 in SGNs and pretreatment with ebselen significantly reduced it, whereas the lack of GPX1 intensified the nuclear fluorescence of NF-B p65 in SGNs of peroxynitrite + gpx1 / group (Figure 8B)

These early changes reflect fat redistribution rather than massive fat loss