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In vivo, blood ammonia primarily originates from the catabolism of amino acids and proteins by bacteria in the gut, hydrolysis of urea, and deamidation of amino acids in liver 2

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10.1007/s00726-011-1206-6 Summary Keywords Pichia pastoris, peptide-crossing-blood-brain-barrier, delta-sleepinducing peptide, neurotransmitter balance, mouse model, PCPA-induced insomnia Citation Mu X, Qu L, Yin L, Wang L, Liu X and Liu D (2024) Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models