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Gholami, O

Enhanced motor capacity was noted in all subjects in a progressive manner that reaches a plateau during the first 3 months of the study

The activation of the IGF-1R leads to a signaling cascade involving the phosphatidylinositide 3-kinase (P13K) and mitogen-activated protein kinase (MAPK) pathways that lead to cell survival and proliferation, which ultimately result in bone elongation (Figure 3)
