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Description
The consequences of impaired methylation pathways are devastating and result in reduced activity of proteins, reduced production of brain neurotransmitters (seretonin, dopamine, GABA etc), increased inflammation, decreased production of glutathione, alterations in DNA and in cell membrane signaling
Therefore, supplementation is needed

10.1038/nrdp.2017.40 25 HigginsJ.GreenS

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