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If vitamin B12 deficiency is caused by disease processes that impair its absorption, it is necessary to constantly and systematically supplement the cobalamin deficiency parenterally for the rest of the patients life

Vascular endothelial cells produce and secrete many physiologically active substances including vasodilators, such as nitric oxide (NO), prostaglandin I 2 , C-type natriuretic peptide, and endothelium-derived vascular hyperpolarizing factor, and vasoconstrictors, such as endothelin, angiotensin II, prostaglandin H 2 and thromboxane A 2 [51, 52]

Peptides studied in regenerative signaling pathways include compounds such as BPC-157 and TB-500 , which researchers investigate for their role in tissue repair and cellular signaling

Masoumi-Ardakani et al