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Biomed Res Int 2021(6652231)

doi: 10.3389/fpsyt.2025.1587432 Received 05 March 2025 Accepted 17 September 2025 Published 23 October 2025 Volume 16 - 2025 Edited by Antonio Narzisi, Stella Maris Foundation (IRCCS), Italy Reviewed by Stefano Marini, Independent Researcher, Termoli, Italy Yitzchak Frank, Mount Sinai Hospital, United States Updates Copyright 2025 Wang and Sun

Studies of histone modifications of IPF lungs found that when treated with histone modification-related drugs (TSA, SpA, etc.), the level of surfactant protein C (Sp-C), the activation and proliferation of fibroblasts are all significantly affected

Some authors have claimed that microbiota alterations have an effect on osteoclastosteoblast activation and skeletal homeostasis regulation via nutritional and immunological pathways and also through bacterial metabolites