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Studies have documented increased nocturnal growth hormone release following DSIP administration, potentially explaining some of the peptide's restorative effects given GH's critical role in tissue repair and metabolic regulation during sleep

d-Amino acids incorporation in the frog skin-derived peptide esculentin-1a(1-21)NH2 is beneficial for its multiple functions

Finishing eating at least 3 hours before bedtime allows substantial gastric emptying before assuming horizontal position
