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It appears to be more accurate than either the Friedewald or Martin equations and can be used for hypertriglyceridaemic samples with TG levels up to 800 mg/dL (9.03 mmol/L): Unlike the other two equations or some of the other past LDL-C equations (2537), the new equation uses higher order mathematical terms in the form of a bivariate quadratic equation that better accounts for the surface to volume relationships that determines the amount of TG in the core of lipoprotein particles (38)

This makes them much more susceptible to environmental stressors