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however, their standardised mortality rate remains 2.87 times higher than that of the general population.1 2 Therefore, achieving remission or mild disease activity and reducing relapses is now a crucial part of the management process for patients with SLE.3 The aetiology and pathogenesis of SLE are complex and may be related to the loss of autoimmune tolerance in response to multiple factors, including genetics, infection and environment, resulting in the appearance of autoantibodies and tissue destruction.4 Oxidative stress has always been a focus of attention for many researchers

doi: 10.1146/annurev.pharmtox.47.120505.105110

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