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Description
This offers new insights into combination strategies involving targeted drugs (such as anti-EGFR or BCL-2 inhibitors) with cuproptosis inducers, which are particularly applicable to drug-resistant tumors with hyperactive mitochondrial metabolism, though further clinical validation is required
Repeated dosing studies in rats, dogs, and mice for up to 6 weeks across doses from 0.006 mg/kg to 20 mg/kg via multiple routes showed excellent tolerance
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White leghorn hens have been used in a 90-day study on the neurotoxic potential of dichlorvos (99.9%) after dermal or oral administration
