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Notably, CA and its active components showed multi-targeted intervention potential for several pathological processes caused by hypoxia, including inhibition of A plaque deposition, regulation of calcium homeostasis imbalance, and modulation of the NF-B/Nrf2 signaling axis (Hambali et al., 2021)

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The systematic review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO), registration number: CRD42024554513 (Available from) ( 2.2 PICOs question The primary research question addressed in this review was: What is the effectiveness of sublingual/oral administration of Vitamin B12 alone or compared to other forms of administration (e.g., intramuscular injection)?

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