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Is the Wolverine Stack safe

Excluding patients who received nelarabine (AALL0434) or bortezomib (AALL1231), the 4-year EFS ( P = .412), OS ( P = .600), cumulative incidence of CNS relapse ( P = .456), and overall relapse ( P = .836) rates were not significantly different between the studies, indicating that the omission of cranial radiation (in the context of the AALL1231 chemotherapy backbone) did not adversely impact outcome

10.1016/s0898-6568(01)00186-183 Cell

This process promotes the sequestration of calcium ions in the sarcoplasmic reticulum while reducing their concentration in the cytosol, which impacts phosphorylation and consequently results in smooth muscle relaxation (Fig