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Firstly, bone marrow iron staining is not a robust test
Upregulated PYCR1 expression has been demonstrated to activate STAT3 phosphorylation in lung cancer, which in turn leads to elevated PD-L1 expression and subsequent inhibition of T cell infiltration [113]
Furthermore, we provide an overview of HIF-1-related drugsboth those approved and those still under clinical investigationwithin the context of the previously outlined regulatory mechanisms
