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Although these findings provide significant mechanistic insight, they primarily originated from animal or in vitro studies, and their translational relevance to long-term human health remains uncertain
Additionally, the development of pharmacological agents that precisely modulate intracellular iron homeostasis, such as iron chelators or iron oxide NPs, or enhance iron bioavailability specifically within the TME, may facilitate the targeted exploitation of ferroptosis pathways
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From a translational perspective, prioritized next steps include well-designed pharmacokinetic and toxicology studies, reproducible efficacy assessments across models, and early-phase clinical trials that emphasize safety and tolerability
