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lean-adjacent n=1 case lost about a third of weight as muscle on 2.5 mg, recovered with resistance work and protein: Almandoz Obes Pillars 2026

Frontiera MS, Stabler SP, Kolhouse JF, and Allen RH (1994)

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In humans, intravenous infusion of PP (10 pmol/kg/min) (supra-physiological levels of PP) in ten healthy volunteers (men and women of normal body weight) caused a sustained decrease in both appetite and cumulative 24-hour energy intake by 25.3 +/- 5.8% (193)