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Description
PCD occurs in 1-5 per 10, 000 population and most commonly manifests between ages 1-7 [28,29]
4.3 Effect on neuro-developmental Throughout the developmental process, the brain exhibits heightened energy demands for synthesizing fundamental cellular structures, neurotransmitters, nucleic acids, proteins, carbohydrates, and lipids that are indispensable for neuronal growth and myelination (46, 47)
& Chen, H
The clinical manifestations and biochemical parameters of isolated MMA patients commonly present during the first weeks and months after birth as poor feeding, recurrent vomiting, and severe metabolic acidosis
