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Preclinical studies have shown that hippocampal mRNA levels of interleukin-1beta (IL-1) and tumor necrosis factor-alpha (TNF-) are increased in a rat model of PTSD, and that substances ameliorating PTSD-related behaviors attenuate the elevation of hippocampal inflammatory cytokine mRNA 8,9

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The role of antioxidant enzymes in regulating oxidative stress related to vascular disease has been previously highlighted (Leopold and Loscalzo 2009)

Serial block face scanning electron microscopy Two-month-old mice were anaesthetized using Avertin (0.5 mg g 1 ) and perfused with 4% paraformaldehyde