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10.1186/s12906-017-1647-x 115 WangY.LuanG.ZhouW.MengJ.WangH.HuN.et al (2018b)

Unfortunately, these drugs all produce treatment-limiting peripheral neuropathy, for which there is no reliable clinical intervention
By increasing leptin levels, obesity alters adipose tissue macrophages (ATMs) metabolism through Janus kinase 3 (JAK3) and STAT3, and PI3K-Akt-mTOR pathways, increasing glycolytic enzymes activity and glucose uptake as well as inducing mitochondrial dysfunctions (247)

[DOI] [PMC free article] [PubMed] [Google Scholar] 70.Stanley CA
