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of ions onto supports led to previously unknown phenomena being uncovered, thereby opening several exciting research directions

Studies with aged mice demonstrated several improvements, including restoration of fur density, improved kidney function, increased physical activity (including running), and overall improvements in age-related frailty markers

This dysfunction is caused by several factors, including vagal dysfunction, impaired activity of interstitial cells of Cajal (ICC), reduced neural nitric oxide synthase activity, and increased oxidative stress[101]