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The M1/M2 classification based on cytokine-induced polarization in vitro is a simplified model that does not reflect the macrophage heterogeneity in vivo

The authors suggested that autophagy inhibited ferroptosis by reducing lipid peroxidation and iron accumulation [92,93,94]

Which type of disease will develop essentially depends on which cells or cell tissues are most severely affected

In support of this, an animal study has demonstrated that oral administration of diallyl trisulfide at a dosage of 12 mg per day for 13 weeks significantly suppressed the progression of invasive carcinoma and multiplicity of pulmonary metastasis (Singh et al., 2008)