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Oxidative stress also activates the Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) redox regulator pathway, releasing Nrf2 to regulate the expression of genes that control antioxidant, inflammatory and immune system responses, facilitating GSH activity

In normal redox balance and low B 6 status, Se-GSH-Px was lower with organic selenium than with inorganic selenium, but both sources of selenium gave equivalent Se-GSH-Px responses when the diet was supplemented with vitamin B 6 (Figure 6)

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