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Mechanisms of diabetes-induced impairment of spermatogenesis Oxidative stress and mitochondrial dysfunction Increased ROS levels and exacerbated oxidative stress are pivotal mechanisms underlying diabetes-related male infertility [106]

Finally, we used Crispr-Cas9 editing to generate a copb-2(zu521) mutation identical to copb-2(gk936767) , and found that it resulted in a similar, semi-dominant nLD phenotype (Fig 13B and 13C)

In PDAC, MEN1 recruits HDACs to deacetylate histones at the CEBPB locus, repressing its transcription and indirectly modulating TGF-/EMT pathways [57]